Protein Details: Glutamate receptor ionotropic; NMDA 1

Protein ID

ICDB_Pro_0494

Protein Name

Glutamate receptor ionotropic; NMDA 1

Gene Name

Grin1; Glurz1

Organism

Mus musculus (Mouse)

Length

938 amino acids

AlphaFoldDB

AF-P35438-F1-model_v4.pdb

Function

Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.

Sequence

MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516..518; /ligand="glycine"; BINDING 523; /ligand="glycine"; ; BINDING 688; /ligand="glycine"; ; BINDING 732; /ligand="glycine";

Disease

Location

Detected in brain (at protein level). Detected in brain.

DOI ID

10.1016/0014-5793(92)80160-i; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1016/0896-6273(94)90350-6; 10.1016/s0169-328x(02)00173-0; 10.1523/jneurosci.23-31-10064.2003; 10.1097/wnr.0b013e328317f05f; 10.1016/j.pbb.2008.09.016; 10.1016/j.cell.2010.12.001; 10.1111/j.1601-183x.2009.00529.x; 10.1038/nm.3117

RefSeq

NP_001171127.1; NP_001171128.1 [P35438-2]; NP_032195.1 [P35438-1]